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PNH—A Life-Threatening Disease
Paroxysmal nocturnal hemoglobinuria (PNH) is a progressive and destructive disease that can cause thrombosis, end-organ damage, and, ultimately, increased mortality.1-3
On this site, you can learn more about the pathophysiology of PNH and the signs and symptoms of the disease, examine a series of case studies, read about diagnosis and testing for PNH, and more.
Healthcare providers interested in learning about PNH pathophysiology or diagnosis and testing can get started with the facts about PNH.
Has your doctor diagnosed you with PNH? For information about your condition, a guide to discussing the disease with your doctor, and more, visit the home page for patients with PNH.
PNH is associated with severe, sometimes life-threatening symptoms. View the video.
PNH Facts
35% of patients with PNH die within 5 years of diagnosis. Thrombosis is the leading cause of death.
Consequences of Hemolysis
Some of the consequences of hemolysis include stroke or TIA, pulmonary embolism or DVT, and end-organ damage to the brain, liver, gastrointestinal tract, or lungs.
Clinical Cytometry Guidelines
Available the way you prefer
Click here to view the ICCS Webcast “Diagnosing and Monitoring of PNH.”
Click here to access a pdf of the new Clinical Cytometry Society Guidelines.
1. Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. N Engl J Med. 1995;333:1253-1258. 2. Socié G, Mary J-Y, de Gramont A, et al; for the French Society of Haematology. Lancet. 1996;348:573-577. 3. Nishimura J-I, Kanakura Y, Ware RE, et al. Medicine. 2004;83:193-207.
