Clinically Assess PNH

A comprehensive critical assessment is crucial to determine the risk for morbidities and premature mortality in your patient with PNH3,4,6,7,9

In addition to looking at outward symptoms, use lab values to help determine your PNH patient’s risk for serious morbidities and premature mortality. Has your PNH patient presented with any of these lab values or symptoms?

* Normal lab values may vary slightly among different laboratories and also between individuals.
Elevated values for this chart were defined by the upper limit, and low levels by the lower limit,
of normal ranges defined by either MedlinePlus, Medscape, or the Mayo Foundation.
†Low haptoglobin is indicative of excess plasma hemoglobin released from hemolyzed RBCs.2

PNH case studies show how lab values and symptoms can be indicative of underlying, life-threatening complications

The following patients underwent more extensive tests when their lab signs and common symptoms indicated the possibility of serious PNH-related morbidities. Click on their test results to find out what underlying and life-threatening complication was revealed.

Patient with elevated SCr8

  • Hemoglobinuria
    • No RBCs in urine under microscope
  • Renal impairment
    • Elevated creatinine: 4.0 mg/dL (female: 0.6-1.1 mg/dL)
  • Signs of hemolysis
    • Elevated LDH: 2454 IU/L (105-333 IU/L)
    • Indirect hyperbilirubinemia: total/direct bilirubin, 3.01/0.71 mg/dL (total, 0.3 to 1.9 mg/dL; direct, 0 to 0.3 mg/dL)
CLICK FOR BIOPSY RESULTS

Patient with dyspnea1

  • Lab values from patients
    with PNH showed:
    • Elevated LDH
    • Elevated NT-proBNP
CLICK FOR MRI RESULTS

Patient with abdominal pain5

  • PNH patient presented with lab
    values and symptoms including:
    • Elevated LDH
    • Elevated bilirubin
    • Low hemoglobin
    • Abdominal pain
CLICK FOR CT SCAN RESULTS

 

 

Clinical Assessment for Risks of Early Mortality

For more information about and help in caring for your patient with PNH, download the Clinical Assessment for Risks of Early Mortality.

PNH Registry

Support scientific collaboration in the PNH community, by helping offer the international community greater insight into an uncommon disease with potentially devastating consequences. Enroll your patients in the PNH Registry today.

PNH Publications

Robust, up-to-date data are essential for proper diagnosis of PNH. View the latest literature on PNH.

References: 1. Hill A, Sapsford RJ, Scally A, et al. Under-recognized complications in patients with paroxysmal nocturnal haemoglobinuria: raised pulmonary pressure and reduced right ventricular function. Br J Haematol. 2012;158:409-414. 2. Rother RP, Bell L, Hillmen P, et al. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293:1653-1662. 3. Hill A, Richards SJ, Hillmen P. Recent developments in the understanding and management of paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2007;137:181-192. 4. Nishimura J-I, Kanakura Y, Ware RE, et al. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine. 2004;83:193-207. 5. Torres J., De Vroey 8, Noel MP, et al. Nat Rev Gastroenterol Hepalol. 2010;7:410-414. 6. Parker C, Omine M, Richards S, et al; for International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-3709. 7. Hill A, Rother RP, Wang X, et al. Br J Haematol. 2010;149:414-425. 8. Tsai C-W, Wu V-C, Lin W-C, et al. Acute renal failure in a patient with paroxysmal nocturnal hemoglobinuria. Kidney Int. 2007;71:1187. 9. Weitz I, Meyers G, Lamy T, et al. Cross-sectional validation study of patient-reported outcomes in patients with paroxysmal nocturnal haemoglobinuria. Intern Med J. 2013;43:298-307.