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Signs and symptoms of PNH

Signs and symptoms of PNH can include a wide range of unpredictable and potentially life-threatening complications1,2,a

Historical data

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Fatigue80%1
Anemia88%-94%3 Dysphagia24%4 Dyspnea64%1
Chest pain33%4 Abdominal pain44%1 Hemoglobinuria62%1
Erectile dysfunctionb38%4

Historical data

~16% to 46%

of PNH deaths were due to venous or arterial thrombosis2,6,7,c-e

~2% to 18%

of PNH deaths were associated with renal failure2,3,d,f

~47%

of patients suffered from pulmonary hypertension8,g

Consequences of PNH

Approximately 20% to 35% of patients with PNH die within 6 years of diagnosis despite historical supportive care3,9,c,h,i

aThe percentages for the signs and symptoms of PNH (with exception of anemia) are from Schrezenmeier 2014 and supplement: PNH Global registry with 856 patients self-reporting symptoms via a baseline questionnaire.1,4

bMale patients only (n=410).4

cRetrospective 6-year survival in historical control patients diagnosed with PNH between 1985 and 2005 in France (N=100). Retrospective thrombosis data presented are also from historical control group (N=44).6

dRetrospective chart review of patients diagnosed with PNH in South Korea (N=301).2

eRetrospective study of patients diagnosed with PNH (N=465) between 1950 and 2005 in France.7

fRetrospective study comparing patients diagnosed with PNH since 1966 from the United States (N=176) to patients with PNH in a database registry in Japan (N=209).3

gData from patients with PNH enrolled in an international phase 3 randomized, placebo-controlled trial between October 2004 and June 2005 (N=87).8

hFive-year survival in patients diagnosed with PNH between 1997 and 2004 in Leeds, UK (N=30).9

iHistorical supportive care included blood transfusion, anticoagulation, immunosuppressive therapy, corticosteroids, and bone marrow transplantation.6,9

PNH Resources

Pathophysiology of PNH

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PNH symptoms video screen

Take a closer look at what causes PNH symptoms

Learn about hemolysis

PNH=paroxysmal nocturnal hemoglobinuria.

Who are patients at high risk for PNH?
References
  1. Schrezenmeier H, et al. Haematologica. 2014;99(5):922-929.
  2. Jang JH, et al. J Korean Med Sci. 2016;31(2):214-221.
  3. Nishimura JI, et al. Medicine (Baltimore). 2004;83(3):193-207.
  4. Schrezenmeier H, et al. Haematologica. 2014;99(5)(suppl):S1-S6.
  5. Schrezenmeier H, et al. Ann Hematol. 2020;99(7):1505-1514.
  6. Loschi M, et al. Am J Hematol. 2016;91(4):366-370.
  7. de Latour RP, et al. Blood. 2008;112(8):3099-3106.
  8. Hill A, et al. Br J Haematol. 2010;149(3):414-425.
  9. Kelly RJ, et al. Blood. 2011;117(25):6786-6792.