PNH case studies reveal hemolysis-related complications

Take a closer look at how assessing lab values and symptoms can indicate underlying, potentially life-threatening complications, including hemolysis, renal impairment, thrombosis, and pulmonary embolism

The following patients underwent more extensive tests when their lab signs and common symptoms indicated the possibility of PNH-related morbidities.

Tap on their test results to find out what underlying and potentially life-threatening complication was revealed.

Patient with elevated sCr1

Female, age 30

  • Presence of red blood cells in urine under microscope
Renal impairment
  • Elevated creatinine: 4.0 mg/dL (female: 0.6-1.1 mg/dL)
Signs of hemolysis
  • Elevated LDH: 2454 IU/L (105-333 IU/L)
  • Indirect hyperbilirubinemia: total/direct bilirubin, 3.01/0.71 mg/dL (total, 0.3 to 1.2 mg/dL; direct, 0 to 0.3 mg/dL)

Patient (group) with dyspnea2

10 patients (median age of 31.5 years)

Lab values from patients with PNH showed:
  • Elevated LDH
  • Elevated NT-proBNP

Patient with abdominal pain3

Female, age 33

Patient with PNH presented with lab values and symptoms including:
  • Elevated LDH
  • Elevated total bilirubin
  • Low hemoglobin
  • Abdominal pain

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LDH=lactate dehydrogenase; NT-proBNP=N-terminal prohormone brain natriuretic peptide; PNH=paroxysmal nocturnal hemoglobinuria; sCr=serum creatinine.

Hear from real people living with PNH
  1. Tsai CW, et al. Kidney Int. 2007;71(11):1187.
  2. Hill A, et al. Br J Haematol. 2012;158(3):409-414.
  3. Torres J, et al. Nat Rev Gastroenterol Hepatol. 2010;7(7):410-414.