Take a closer look at how assessing lab values and symptoms can indicate underlying, potentially life-threatening complications, including hemolysis, renal impairment, thrombosis, and pulmonary embolism
The following patients underwent more extensive tests when their lab signs and common symptoms indicated the possibility of PNH-related morbidities.
Tap on their test results to find out what underlying and potentially life-threatening complication was revealed.
From Tsai CW, et al. Kidney Int. 2007;71(11):1187.
© 2007 International Society of Nephrology.
A renal biopsy of the patient, following diagnosis, revealed extensive kidney damage and hemosiderin accumulation associated with high LDH and low haptoglobin indicative of intravascular hemolysis. (a) Pigment deposits.* (b) Tubular necrosis and degeneration.
*Arrows indicate pigment deposits.
From Hill A, et al. Br J Haematol. 2012;158(3):409-414.
©2012 Blackwell Publishing Ltd
Six out of 10 patients were observed to have subclinical small pulmonary emboli recognized by MRI.
Imaging shows multiple perfusion defects in the posterior aspects of the lungs of a patient with PNH.*
From Torres J, et al. Nat Rev Gastroenterol Hepatol. 2010;7(7):410-414.
© 2010 Macmillan Publishers Limited.
Abdominal CT scan of the case patient at admission. The scan shows parietal thickening of the second portion of the duodenum (arrows).