PNH - Please select who you are:

High-Risk Patient Groups


Early diagnosis is essential for improved patient management and prognosis1,2

High-risk groups for PNH1-6

Coombs-negative hemolytic anemia
Hemoglobinuria or Hemosiderinuiria
Renal dysfunction
Aplastic anemia
MDS
Cytopenia
Venous or arterial

Test for PNH using high-sensitivity flow cytometryc performed on peripheral blood3

These guidelines are intended as educational information for healthcare providers. It does not replace a healthcare provider’s professional judgment or clinical diagnosis.

IDA, iron deficiency anemia.

aAnemia, neutropenia, thrombocytopenia, or pancytopenia.
bUnusual sites include hepatic veins (Budd-Chiari syndrome), other intra-abdominal veins (portal, splenic, splanchnic), cerebral sinuses, and dermal veins.
cDetects PNH cells down to a 0.01% clone size.


The diverse and common symptomatology of PNH can delay diagnosis. Find out about the variety of symptoms that can occur in a patient with PNH.

Do you have any questions about PNH? Contact an Alexion Nurse Case Manager for more information.

References: 1. Morado M, et al. Cytometry B Clin Cytom. 2017;92(5):361-370. 2. Borowitz MJ, et al. Cytometry B Clin Cytom. 2010;78(4):211-230. 3. Sharma VR. Clin Adv Hematol Oncol. 2013;11 Suppl 13(9):2-8. 4. Parker C, et al. Blood. 2005;106(12):3699-3709. 5. Rachidi S, et al. Eur J Intern Med. 2010;21(4):260-267. 6. Hill A, et al. Blood. 2013;121(25):4985-4996. 7. Dezern AE, et al. Cytometry B Clin Cytom. 2018;94(1):16-22. 8. Hillmen P, et al. Am J Hematol. 2010;85(8):553-559. 9. Sahin F, et al. Am J Blood Res. 2016;6(2):19-27. 10. Brodsky RA. In: Hoffman R, et al, eds. Hematology: Basic Principles and Practice. 4th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2005:419-427. 11. Tiu R, et al. Leukemia. 2007;21(8):1648- 1657. 12. Kinoshita T, Inoue N. Int J Hematol. 2002;75(2):117-122. 13. Raghupathy R, et al. Case Rep Hematol. 2012;2012:106182. 14. Pu JJ, et al. Eur J Haematol. 2011;87(1):37-45. 15. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Myeloc dysplastic syndromes. Version 2.2014. http://www.nccn.org/professionals/physiciangls/pdf/mds.pdf. Accessed February 10, 2014. 16. Raza A, et al. Cytometry B Clin Cytom. 2014;86(3):175-182. 17. Brodsky RA. Blood. 2009;113(26):6522-6527. 18. Cytopenia. Dorland’s Illustrated Medical Dictionary. 32nd ed. Philadelphia, PA: Elsevier Saunders; 2012. 19. Murakami Y, et al. Blood. 2002;100(12):4116-4122. 20. de Latour RP, et al. Blood. 2008;112(8):3099-3106. 21. Young NS, et al. Hematology Am Soc Hematol Educ Program. 2000:18-38. 22. McKeage K. Drugs. 2011;71(17):2327-2345. 23. Lee JW, et al. Haematologica. 2010;95(s2):205-206. 24. Mohanty BD, et al. Am J Med. 2012;125(3):243-245. 25. Urbano-Ispizua A, et al. Blood. 2011;118:2102. 26. Hill A, et al. Br J Haematol. 2012;158(3):409-414.

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