PNH - Please select who you are:

Comorbidities and Consequences

PNH is a chronic, hemolytic disease with risk of unpredictable and life-threatening complications1

  • Approximately 20%-35% of patients with PNH (receiving historical supportive care, including oral anticoagulant therapy and transfusions) die within 5-10 years of diagnosis2-5

Learn more about some of these life-threatening complications by clicking on the links below.

Thrombosis is the leading cause of death in PNH, and even the first thrombotic event can be fatal6
64% of patients with PNH have chronic kidney disease (CKD), which in advanced stages is associated with premature mortality7


Early diagnosis is essential for improved patient management and prognosis. Learn about ICCS and other expert recommendations for who should be tested for PNH.

PNH has been called “the most vicious acquired thrombophilic state known in medicine”.8 Learn which common symptoms are associated with an increased risk of thromboembolism in a patient diagnosed with PNH.

References: 1. Hillmen P, et al. Br J Haematol. 2013;162(1):62-73. 2. Peffault de Latour RP, et al. Blood. 2008;112(8):3099-3106. 3. Loschi M, et al. Am J Hematol. 2016;91(4):366-370. 4. Kelly RJ, et al. Blood. 2011;117(25):6786-6792. 5. Hillmen P, et al. N Engl J Med. 1995;333(19):1253-1258. 6. Hillmen P, et al. Blood. 2007;110(12):4123-4128. 7. Hillmen P, et al. Am J Hematol. 2010;85(8):553-559. 8. Hill A, et al. Blood. 2013;121(25):4985-4996. 9. Sharma VR. Clin Adv Hematol Oncol. 2013;11 Suppl 13(9):2-8. 10. Lee JW, et al. Int J Hematol. 2013;97(6):749-757. 11. McKeage K. Drugs. 2011;71(17):2327-2345.