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Pathophysiology


Pathophysiology of PNH

The complications from PNH are devastating and systemic. The pathophysiology behind these complications, while complement-mediated, is multifactorial in nature.1-7


PNH has been called “the most vicious acquired thrombophilic state known in medicine”.3 Learn which common symptoms are associated with an increased risk of thromboembolism in a patient diagnosed with PNH.

References: 1. Kelly R, et al. Ther Clin Risk Manag. 2009;5:911-921. 2.Rother RP, et al. JAMA. 2005;293(13):1653-1662. 3. Hill A, et al. Blood. 2013;121(25):4985-4996.4. Zatz R, Baylis C. Hypertension. 1998;32(6):958-964. 5. Rachidi S, et al. Eur J Intern Med. 2010;21(4):260-267. 6. Hill A, et al. Br J Haematol. 2010;149(3):414-425. 7. McKeage K. Drugs. 2011;71(17):2327-2345.

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